Since the authorization of the Moderna and Pfizer–BioNTech vaccines in December 2020, over 10,000 pregnant women, many were health-care workers, have been vaccinated. Dr Fauci has noted that there is evidence that a coronavirus infection can lead to heightened risk of an adverse outcome in pregnancy, which might be why many pregnant health-care workers decided to get the vaccine. There are “de-escalation studies” underway for younger children. These studies will look at the safety and effectiveness of the vaccines in progressively younger and younger children. Data from those studies should be available in the next few months.